Corticobasal Ganglionic Degeneration and Progressive Supranuclear Palsy: Clinical and Speech-Language Characteristics Purpose: The purpose of this article is to present a brief description of the neuroanatomical correlates, pathophysiology, and clinical presentation of corticobasal ganglionic degeneration, (often referred to as corticobasal degeneration, or CBD) and progressive supranuclear palsy (PSP). Methods: Descriptions of the clinical characteristics of the two degenerative syndromes are presented, ... Article
Article  |   June 01, 2010
Corticobasal Ganglionic Degeneration and Progressive Supranuclear Palsy: Clinical and Speech-Language Characteristics
Author Affiliations & Notes
  • Edythe A. Strand
    Division of Speech Pathology, Department of Neurology, Mayo Clinic, Rochester, MN
Article Information
Speech, Voice & Prosodic Disorders / Apraxia of Speech & Childhood Apraxia of Speech / Dysarthria / Special Populations / Genetic & Congenital Disorders / Older Adults & Aging / Language Disorders / Aphasia / Articles
Article   |   June 01, 2010
Corticobasal Ganglionic Degeneration and Progressive Supranuclear Palsy: Clinical and Speech-Language Characteristics
SIG 2 Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders, June 2010, Vol. 20, 45-49. doi:10.1044/nnsld20.2.45
SIG 2 Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders, June 2010, Vol. 20, 45-49. doi:10.1044/nnsld20.2.45
Abstract

Purpose: The purpose of this article is to present a brief description of the neuroanatomical correlates, pathophysiology, and clinical presentation of corticobasal ganglionic degeneration, (often referred to as corticobasal degeneration, or CBD) and progressive supranuclear palsy (PSP).

Methods: Descriptions of the clinical characteristics of the two degenerative syndromes are presented, including a discussion of the similarities and differences. The speech and language disorders associated with each are described, including progressive aphasia, progressive non-fluent aphasia (PNFA), progressive apraxia of speech (AOS), and dysarthria.

Results and Conclusions: CBD and PSP have a number of commonalities in clinical characteristics and in pathology. Both progressive aphasia and apraxia of speech have been associated with CBD and PSP. Clinicians who evaluate patients exhibiting a progressive neurologic disease and who identify either progressive aphasia, PNFA and/or progressive AOS should consider CBD or PSP as a possible medical diagnosis.

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