Primary Progressive Aphasia and Its Three Variants Speech-language pathologists are increasingly treating patients with progressive disorders, including primary progressive aphasia (PPA). For many years, two variants of PPA were recognized: a nonfluent type—progressive nonfluent aphasia (PNFA)—and a fluent form—semantic dementia (SD). In 2004, a third variant—logopenic progressive aphasia (LPA)—was described. This article will review clinical symptoms, neuroimaging ... Article
Article  |   April 01, 2010
Primary Progressive Aphasia and Its Three Variants
Author Affiliations & Notes
  • Jennifer M. Ogar
    Memory and Aging Center, University of California, San Francisco, CA
Article Information
Special Populations / Older Adults & Aging / Language Disorders / Aphasia / Articles
Article   |   April 01, 2010
Primary Progressive Aphasia and Its Three Variants
SIG 2 Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders, April 2010, Vol. 20, 5-12. doi:10.1044/nnsld20.1.5
SIG 2 Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders, April 2010, Vol. 20, 5-12. doi:10.1044/nnsld20.1.5
Abstract

Speech-language pathologists are increasingly treating patients with progressive disorders, including primary progressive aphasia (PPA). For many years, two variants of PPA were recognized: a nonfluent type—progressive nonfluent aphasia (PNFA)—and a fluent form—semantic dementia (SD). In 2004, a third variant—logopenic progressive aphasia (LPA)—was described. This article will review clinical symptoms, neuroimaging correlates, and the neuropathologies that are typically associated with PNFA, SD, and LPA. Case studies are included to further illustrate the characteristics of each of these three PPA variants.

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